- Muscle Building: Ostarine (MK-2866) is one of the most popular SARMs for muscle
preservation and lean mass gains. It selectively binds to androgen receptors, resulting
in significant anabolic activity in muscle tissue. At higher doses (like 50mg per day), it
promotes muscle hypertrophy and strength. It’s often used for bulking or during a
recomposition phase. - Fat Burning: Ostarine is also beneficial for fat loss. It helps preserve
muscle mass during a calorie deficit, making it easier to maintain strength and
performance. It has a mild impact on metabolism, aiding in overall body composition
improvements. - Ostarine is a second-generation selective androgen receptor modulator (SARM), also referred to as Enobosarm or MK-2866.
- The objective with the formulation of ostarine and other SARMs is to mimic the anabolic effects of steroids without the harsh side effects. This potentially will ensure a safer and more efficacious treatment for patients suffering from cachexia, osteoporosis, and anemia.
- GTx, Inc., a US biotechnology firm, first described and developed MK-2866 in 2001. Since then, phase 1, 2, and 3 clinical trials have evaluated it.
- In phase 3 trials, GTx announced that ostarine was unsuccessful in the treatment of breast cancer patients suffering from cachexia. This was due to insignificant improvements in muscular strength, despite increases in muscle hypertrophy.
- This has led GTx to cease its pursuit of ostarine for the treatment of cachexia. However, the biotechnology company remains committed to modifying MK-2866 for improved success in the future.
- Given its recent creation, the FDA has not approved ostarine for human use. Consequently, sporting organizations like WADA prohibit its acquisition for cosmetic purposes. It is also illegal to use ostarine for cosmetic purposes, with only scientific research permitted.
