Tyrosol, the next upcoming ingredient to hit the supplement market?


Tyrosol is a phenylethanoid, a derivative of phenethyl alcohol. It is a natural phenolic antioxidant present in a variety of natural sources The principal source in the human diet is olive oil but it is also found in wines and green tea.  As an antioxidant, tyrosol can protect cells against injury due to oxidation. This effect may contribute significantly to the health benefits of olive oil and, more generally, the Mediterranean diet. The main job of any antioxidant is to protect cells and tissue from oxidative injury. Oxidative injuries to the brain can cause Parkinson’s disease as well as Alzheimer’s disease and other forms of dementia. Oxidative injuries can also cause cancer and heart disease.  Tyrosol presents a significant antioxidant effect in olive due to its good bioavailability and its high concentration in Olive oil.  How strong is Tyrosol?   Tyrosol is one of the strongest antioxidants on the planet! It can get rid of inflammatory free radicals ten times better than green tea, and twice as well as CoQ10. But tyrosol’s main effect is that it turns on a group of longevity genes called “forkhead box” genes, or FOXOs. FOXO genes are part of the equation your body uses to signal your cells to begin telomere repair. Think of FOXO genes as a kind of gauge, they determine if you have enough antioxidants for repairs to begin. When there is too much oxidation, too many free radical attacks, your body can’t keep up with telomere repair. But when your oxidative stress is lowered your body can get ahead of the game. Therefore, antioxidants are especially important. They protect your cells while your body makes repairs. After FOXOs give the green light for telomere repair, they also have another role. They shut down aging of certain cells when under oxidative attack. Tyrosol then directly increases amounts of the body’s “master antioxidant,” superoxide dismutase “SOD”.

Tyrosol has numerous potential health benefits, here are some of the benefits shown through research currently:

– has a neuroprotective effect on the brain.

– shown to be cardioprotective.

-Significant increase in the phosphorylation of Akt, eNOS and FOXO3a in tyrosol treated animals

-may be considered as anti-aging therapy for the heart.

– induced the expression of longevity protein SIRT1 in the heart after myocardial infarction in rat MI model.

– it possesses potent activity against several strains of bacteria responsible for intestinal and respiratory infections in vitro. Antibacterial properties of Tyrosol can be linked to the binding and inhibition of bacterial ATP synthase.

– able to increase the longevity of C. elegans and could ameliorate hyperglycemia in diabetic rats.  Previously, our data showed that tyrosol prevents endoplasmic reticulum (ER) stress-induced apoptosis in pancreatic β-cells through JNK signaling, suggesting that tyrosol could be a potential therapeutic candidate for the amelioration of type 2 diabetes. (1)

– has shown preventing or inhibiting atherogenesis antiatherogenic effects There also was no clear evidence that beta carotene inhibits the oxidation of low-density lipoproteins, the principal proposed mechanism of its postulated antiatherogenic properties, cardioprotective, anticancer, neuroprotective and endocrine effects.

– could exert its beneficial effects against hypertension, atherosclerosis, coronary heart disease, chronic heart failure, insulin resistance and obesity by modulating cluster of differentiation 14 (CD14) up-regulation and inhibiting inflammation [3] Tyrosol reduces oxidative modifications to HDL and by maintaining the physicochemical properties of HDL, improves the functionality of HDL, especially the capacity to promote cholesterol efflux. It also posseses antiatherogenic activity due to inhibition of leukotriene B4 production that affects endothelial function.

– has been evaluated as promising substance that affects microcirculation, taking into account its hemorheological activity. For example, experiments in vitro showed that Tyr constrains the increase in blood viscosity and the effect of Tyr was comparable to that of pentoxyphylline. Also, the effect of Tyrosol on hemorheological parameters and cerebral microvascularization in spontaneously hypertensive rats was investigated at the stage of BP rising, and it was shown that Tyrosol limits the development of hyperviscosity syndrome, improves oxygen transport capacity and eliminates microvascular rarefaction in the cerebral cortex .

– Tyrosol treatment ameliorated hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Tyrosol may also play an important role in the treatment of Diabetes Mellitus, as it exerts anti-inflammatory effects on the liver and pancreas of streptozotocin-induced diabetic rats, and inhibits endoplasmatic reticulum stress-induced apoptosis in pancreatic β-cell ; dysfunction of pancreatic β-cells is a major determinant for the development of type 2-Diabetes Mellitus.

– prevented osteopenia by increasing bone formation, probably because of its antioxidant properties

– it was shown that the absorbed Tyrosol could be interconverted into Hydroxytyrosol in liver microsomes by the activity of CYP2A6 and CYP2D6, so Tyrosol could be a precursor of Hydroxytyrosol.  Neither tyrosine nor tyramine was found to generate Hydroxytyrosol.

-Tyrosol is shown to be cardioprotective, and has shown that tyrosol-treated animals showed significant increase in the phosphorylation of Akt, eNOS and FOXO3a. In addition, tyrosol also induced the expression of longevity protein SIRT1 in the heart after myocardial infarction in a rat MI model

– Tyrosol is shown to be cardioprotective, and has shown that tyrosol-treated animals showed significant increase in the phosphorylation of Akt, eNOS and FOXO3a. In addition, tyrosol also induced the expression of longevity protein SIRT1 in the heart after myocardial infarction in a rat MI model. These findings suggest that tyrosol induces myocardial protection against ischemia related stress by inducing survival and longevity proteins that may be considered as anti-aging therapy for the heart.

-Tyrosol and its hydroxytyrosol conversion improve HDL cholesterol, vasodilatory, and inflammatory markers.


So what does all of this mean?   In my opinion, Tyrosol is the next big upcoming ingredient to hit the supplement market.  The potential benefits are vastly impressive with no real negatives! Tyrosol is one of the most potent antioxidants you can take and has numerous health benefits as you can see above.  I believe tyrosol has been overlooked for too long and we want to show everyone how beneficial this ingredient can be for promoting and maintaining health.  There is not much out there in the form of supplements using this ingredient yet.  Iron Forged Nutrition just released it’s liver, Kidney, and heart support supplement called C.E.R.T. which is the first product I have seen using 100mg of Tyrosol per cap.  Everything else I have come across has 10mg or similar.  If you want to check out Iron Forged Nutrition’s C.E.R.T. Follow the link to it’s product page.   There has been a lot of research done on this ingredient.   From what we have seen the results have been nothing short of amazing.   This could be a game changer in the world of health supplementation.   Remember the name because this will not be the last time you hear about Tyrosol In the next few years we promise you that!

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