Sermorelin Acetate Review
Sermorelin Acetate Review
by Trevor Benko
What is Sermorelin Acetate exactly and what does it do?
Sermorelin Acetate Review- Sermorelin Acetate is a synthetic analog of endogenous growth hormone-releasing hormone (GHRH or GRF). Sermorelin is a portion of this polypeptide hormone, specifically consisting of the first 29 of its 44 amino acid structure. This is a twenty nine-amino acid polypeptide which represents 1-29 fragment by endogenous HGH Releaser Hormone which is considered to be the quickest completely functional fragment of GHRH. As its name states very clearly, the biological activity of GHRH is to stimulate the synthesis of growth hormone, which occurs in the pituitary gland. It has been shown that GHRH can be shortened without losing it’s GH stimulating ability. Sermorelin is considered a Growth Hormone Releasing Factor (GHRF) or GH Secretagogue. As an Acetate it has been used in medicine as a way to diagnose pituitary deficiency and is a treatment for growth hormone deficiency in children. Sermorelin is a very specific acting drug, and has no effect on prolactin, LH, FSH, insulin, cortisol, glucose, glucagon, or thyroid hormone levels. This makes it a potential candidate for therapeutic use. Athletes are interested in Sermorelin for the same reasons they are HGH. It has an anabolic effect as well as a powerful anti-catabolic effect. Higher GH levels can support muscle tissue growth, support tendon strength, enhance energy levels, and could increase strength. Increased GH levels can also help with fat loss . This makes it popular with the bodybuilding community and sermorelin is becoming more widely accepted as a replacement for low dose GH therapy or use. With long term use the body can develop anti bodies to GHRH in some people and this could cause sermorelin to be less effective.
For most people a growth hormone deficiency begins to occur around 30yrs of age. A decline that will increase of about 14% for each year after the age of 30. Impaired sleep and incapacity to exercise as effectively (low energy , achy joints, added bodyfat) are some of the main symptoms. Sermorelin is made to boost the natural hormone production. This should help reverse many of the signs of aging and restore vitality. While sermorelin will produce significant elevations in GH and IGF-1, these levels should not exceed the high end of the normal range. This may make sermorelin acetate a more comfortable option for some patients. Studies seem to support this notion, finding many of the same physical and metabolic benefits of GH injections, without reporting the same issues with insulin resistance, fluid retention, or muscle pain.
HGH and Sermorelin Acetate Therapy provide similar benefits
Human growth hormone therapy and Sermorelin Acetate Review therapy have substantially the same treatment benefits because injected recombinant human growth hormone (somatropin) medication is genetically engineered to have the same DNA structure as human growth hormone produced by the pituitary gland when stimulated by Sermorelin injections. Sermorelin is a human growth hormone secretagogue, it effects your pituitary gland to create more HGH. Sermorelin is known as a tiny peptide that contains just twenty nine amino acids while HGH is actually a larger molecule that contains 191 amino acids. The benefits of Sermorelin therapy or recombinant human growth hormone therapy include the following:
- Increases the development of lean body mass through the development of new muscle cells
- Reduces body fat through lipolysis
- Increases energy and vitality
- Increases strength
- Increases endurance
- Accelerates healing from wounds or surgery
- Strengthens the heart
- Enhances the immune system
- Increases IGF-1 production
- Improves sleep quality
- Increases calcium retention, and strengthens and increases the mineralization of bone or bone density.
- Increases protein synthesis and stimulates the growth of all internal organs except the brain.
The cost of Sermorelin therapy is typically less than one half the cost of recombinant human growth hormone (somatropin) therapy due to the higher cost of the genetically engineered human growth hormone medication. Even though the compounds act on totally different parts in your body (HGH in the liver and Sermorelin in the pituitary), the quantity of substance required to be useful in increasing serum IGF-1 are usually almost identical. HGH is mostly prescribed in every day dosages of 1 or 2 international units (IU) although Sermorelin is actually prescribed into micrograms.
Nevertheless, 1 IU is equivalent to 333 micrograms and so the weight of efficient doses is nearly between three hundred and six hundred micrograms a day. All the beneficial doses for Sermorelin tend to be between two hundred to five hundred micrograms a day; a range that is similar to that for Human growth hormone.
Sermorelin is used by shot daily just before going to bed. The moment of injections is essential for the reason that extra GRF supplied by Sermorelin supplements that which normally happens while sleeping and also thereby helps the night time release of HGH which is typical of youngsters. Dosage range must be fitted to everyone’s personal requirements. Nevertheless, recommendations for dosing are usually:
- 200 ug/day for males with BMI via 18.5 / 24.9
- 300 ug/day for males with BMI among 25 / 29.9
- 400 ug/day for females and males with BMI among 25 / 29.9
- 500ug/day for females and males with BMI among 25 / 29.9
I personally went up to a max of 1mg of Sermorelin acetate per injection for about 2 months and didn’t notice much more benefits over the .500 mcg dose so I went back down and finished out my 6 months of use there.
Sermorelin Acetate Review : Background and Structural Information
Sermorelin Acetate Review History: Sermorelin acetate was developed during the early 1980s, and approved for prescription sale by the U.S. Food and Drug Administration in 1997. It was introduced to market under the brand name Geref Diagnostic by the international biotechnologies firm Serono. As the name implies, it was primarily developed as a diagnostic tool. It was specifically used for evaluating potential pituitary deficiency in GH production. Given its effect on growth hormone levels, however, the drug was also approved by the FDA for the treatment of GH deficiency in children. Geref was never widely prescribed, however, especially for uses relating to childhood GH deficiency, where it was never able to compete with somatropin. Serono ultimately discontinued the product in October 2008, citing supply issues with the active pharmaceutical ingredient This was the only company manufacturing sermorelin as a commercial product in the United States, thus it is no longer available as a stock pharmacy item.The active material sermorelin acetate is still made by at least one licensed supplier, however, so the drug remains available here as a compounded medicine.
Sermorelin Acetate Review – How it is Supplied: The original Geref Diagnostic was supplied in ampules containing dry lyophilized sermorelin acetate, equivalent to 50 mcg of sermorelin. Now many compound pharmacies will supply the drug in a 10ml Multiuse Vial containing 15mg or sermorelin acetate in a dry lyophilized Tablet. This is or was reconstituted with a sterile diluent such as bacteriostatic water (also supplied with prescription in most cases) before use. Generic compounded versions of this medication typically contain between 3.0 and 7.5 mg of dry lyophilized sermorelin acetate in a multi-dose vial. Reconstitution before use is also required.
Sermorelin Acetate Review – Structural Characteristics: Sermorelin acetate is the acetate salt of a synthetic 29–amino acid peptide (GRF 1-29 NH 2) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH) with 44 amino acid residues.
Sermorelin Acetate Review – Warnings: Sermorelin acetate should be used with care in epileptic patients. Obesity, uncontrolled hypothyroidism, hyperglycemia, or elevated plasma fatty acids may impair the effectiveness of sermorelin. Therapy should be discontinued in patients treated for childhood GH deficiency once the epiphyses have closed.
Sermorelin Acetate Review – Side Effects: The most common side effects to sermorelin acetate therapy are injection site reactions such as pain, redness, and swelling. This is something I experienced myself more than a few times during my During clinical trials, this occurred in approximately 17% of patients. Less common side effects include difficulty swallowing, itching, dizziness, flushing, headache, nausea, vomiting, altered sense of taste, restlessness, and sleepiness.
If some of these effects continue or get worse, inform your physician. Quickly inform your physician if these unlikely negative effects appear: flushing, boost in hyperactivity, headache.
In under one percent from the people prescribed Sermorelin in medical studies, symptoms such as:
- dizzy spells
- urticaria appeared
- Facial flushing
- swelling at injection site
- strange taste in mouth
Inform your doctor right away if these unlikely but really serious side effects appear: trouble swallowing, chest tightness, vomiting. An allergy to the drug is not likely; however look for fast medical assistance if it takes place. The signs of an allergic attack contain: rash, swelling, itching, trouble breathing and dizziness. You may notice additional side effects not listed in this article, speak to your physician.
Sermorelin Acetate Review – Administration: When used medically for the treatment of idiopathic growth hormone deficiency in prepubertal children with growth failure, sermorelin acetate is administered by subcutaneous injection at a dosage of 0.03 mg per kg of body weight once a day at bedtime. Injection sites should be rotated to avoid irritation or the buildup of scar tissue. When used to evaluate pituitary capacity in adults, a single intravenous infusion of 1.0 mcg/kg body weight is administered in the morning after an overnight fast.This is followed by 60-120 minutes of periodic blood sampling to measure pituitary hormone output. When used for physique- or performance-enhancing purposes, sermorelin acetate is given by subcutaneous injection. It is typically administered at a dosage of 0.2 to 0.5 mg per day (200-500 mcg), which is given before sleep. Studies, however, do suggest that this drug is more effective when given twice daily.716 Therefore, it is often preferred to divide the total daily dosage into two applications,one in the morning and one in the evening. Cycles of sermorelin acetate usually last between 8 and 12 weeks. Some anti-aging practitioners will prescribe the medication for much longer periods of time, however, and cycles lasting 24-48 weeks are not uncommon.The hope is that the extended maintenance of youthful growth hormone levels will yield more significant physiological changes.
Sermorelin Acetate Review – Availability Trends: Sermorelin acetate is subject to limited availability as a pharmaceutical product. It is prescribed by many anti-aging clinics and produced in Compounding pharmacies. The vast majority of preparations on the black market come from underground or gray market suppliers.
My Sermorelin Acetate Review
My Sermorelin Acetate Review is that I personally feel that there is definitely some noticable benefits with Seromorelin Acetate use. I felt that I got more from my sleep. What I mean by that is if I slept for 5 hrs it felt more like I slept 8 hrs. I noticed substantial benefits in my recovery meaning less soreness and better healing of injuries. When I started taking Sermorelin I was dealing with a bad shoulder injury that had been nagging me for almost 2 yrs straight. It had finally gotten to the point that I could barely do a pushup without severe pain. After being on sermorelin for 8wks at 500mcg a day I noticed that my shoulder was actually getting better. Not overnight but slowly coming around. At that point I was able to start training chest again which had been nearly impossible up until that point. It didn’t heal my shoulder altogether but it did make it more manageable. I believe it was an important piece to the puzzle to help with the healing . I think Sermorelin worked very well for me even though I am young 29 yrs old because of how bad my sleep was before starting Sermorelin. Sleep has always been an issue with me. Sermorelin also helped me get more sleep because after doing the SubQ injection I would get a warm flushed feeling that helped me fall asleep and stay asleep. Another benefit I noticed was the fat burning effect. I believe this had a lot to do with the fact that I would try not to eat carbs carbs around the time of my injection or after the injection in an effort to allow the Sermorelin to boost IGF-1 more effectively. Overall I was very happy with my experience and would recommend Sermorelin to anyone who feels they have low GH levels over the age of 30 unless you have severe sleep issues like myself then it maybe beneficial for those closer to 30 as well. I would compare it to a low dose of HGH and being that you are boosting the body’s production naturally I feel that it is much safer and helps prevent abuse. It also is supposed to lead to higher HGH and IGF-1 levels for up to two years after use is discontinued. I am not sure that is true but I can see that it may boost your natural production for a few months after use is discontinued. For the money I think it is a good value and well worth it for anyone looking for the benefits of HGH but not wanting to risk the side effects or spend so much money. The only side effects I noticed were some injection site irritation from time to time and a flushed feeling after the injection occasionally. All in all I was very impressed and would use it again in the future. Check out the attached video for info on how to reconstitute and inject Sermorelin Acetate.
References: 702. Stimulation of growth hormone secretion with human growth hormone releasing factors (GRF1-44, GRF1-40, GRF1-29) in normal subjects. Losa M, Schopohl J, Müller OA, von Werder K. Klin Wochenschr. 1984 Dec 3;62(23):1140-3. 703. Testing with growth hormone-releasing factor (GRF(1-29)NH2) and somatomedin C measurements for the evaluation of growth hormone deficiency. Ranke MB, Gruhler M, Rosskamp R, Brügmann G, Attanasio A, Blum WF, Bierich JR. Eur J Pediatr. 1986 Dec;145(6):485-92. 704. Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group. Thorner M, Rochiccioli P, Colle M, Lanes R, Grunt J, Galazka A, Landy H, Eengrand P, Shah S. J Clin Endocrinol Metab. 1996 Mar;81(3):1189-96. 705. Growth hormone responses to growth hormone-releasing hormone (1-29)-NH2 and a D-Ala2 analog in normal men. Barron JL, Coy DH, Millar RP. Peptides. 1985 May-Jun;6(3):575-7. 706. A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiency. Chen RG, Shen YN, Yei J, Wang CF, Xie DH, Wang XH, Zhou JD, Chen CY, Wu YL, Gunnarsson R, et al. Acta Paediatr Suppl. 1993 Mar;388:32-5; discussion 36. 707. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. Prakash A, Goa KL. BioDrugs. 1999 Aug;12(2):139-57. 708. Continuous subcutaneous GHRH(1-29)NH2 promotes growth over 1 year in short, slowly growing children. Brain CE, Hindmarsh PC, Brook CG. Clin Endocrinol (Oxf ). 1990 Feb;32(2):153-63. 709. Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group. Thorner M, Rochiccioli P, Colle M, Lanes R. et al. J Clin Endocrinol Metab. 1996 Mar;81(3):1189-96. 710. Growth hormone (GH) profiles in response to continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 in children with GH deficiency. Tauber MT, Pienkowski C, Pigeon P, Cataldi M, Rochiccioli P. Acta Paediatr Suppl. 1993 Mar;388:28-30; discussion 31. 711. Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormone. Neyzi O, Yordam N et al. Acta Paediatr Suppl. 1993 Mar;388:16-21; discussion 22. 712. Growth Hormone–Releasing Hormone in HIV-Infected Men With Lipodystrophy A Randomized Controlled Trial. Polyxeni Koutkia; Bridget Canavan; Jeff Breu; et al. JAMA, July 14, 2004—Vol 292, No. 2. 713. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL. Science. 1981 Jun 12;212(4500):1279-81. 714. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Walker RF. Clin Inte
Aging. 2006;1(4):307-8. 715. EMD Serono, Inc. to Discontinue Geref Diagnostic 8/5/2008 716. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Vittone J, Blackman MR, BusbyWhitehead J. et al. Metabolism. 1997 Jan;46(1):89-96.
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