Black Lion Research Ultimate Anti-Estrogen Stack [Exotherm, Rebirth, Letrone] - TGB Supplements
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Black Lion Research Ultimate Anti-Estrogen Stack [Exotherm, Rebirth, Letrone]

$149.59 $134.30

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Black Lion Research Ultimate Anti-Estrogen Stack [Exotherm, Rebirth, Letrone]

$149.59 $134.30

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Black Lion Research Ultimate Anti-Estrogen Stack [Exotherm, Rebirth, Letrone]

Black Lion Research Ultimate Anti-Estrogen Stack [Exotherm, Rebirth, Letrone] *EXOTHERM is designed to reduce estrogen and shred off bodyfat. This cosmetic transdermal has been shown to be one of the strongest lean gainers ever developed. -Lean dry gains -Fat loss -Anti estrogen -Increase IGF -Boost natural testosterone This is the next generation of aromatase inhibition.  Formeron was a huge success because it produced results that were visible via blood test and the mirror.  Don’t expect anything less from Exotherm.  This product not only can do what formeron was known for but even more.   The added fat burning effect is very noticeable and expect results that you can feel.  I was lucky enough to be a tester for this product and I can tell without a doubt that this product gets my full recommendation for anyone looking to control estradiol and get that hard grainy look. Rebirth can be used to mitigate Gyno by blocking the estrogen receptor and not allowing it to be bound to. Also it is very applicable in the PCT Period to kickstart your HPTA to start your own production back ASAP. Combine Rebirth with a Aromatase Inhibitor and your PCT is set. With absorption enhancers this product will deliver shocking results.

Ellagic Acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. Whether this compound has estrogenic/antiestrogenic activity, however, remains largely unknown. To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. Cells co-transfected with an estrogen response element (ERE)-driven luciferase (Luc) reporter gene and an ERalpha- or ERbeta-expression vector were exposed to graded concentrations of ellagic acid. At low concentrations (10(-7) to 10(-9) M), this compound displayed a small but significant estrogenic activity via ERalpha, whereas it was a complete estrogen antagonist via ERbeta. Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). These findings suggest that ellagic acid may be a natural selective estrogen receptor modulator (SERM).
PMID:
16190622
[PubMed – indexed for MEDLINE]

Eucheuma cottoni

The edible red seaweed Eucheuma cottonii is abundantly cultivated for carrageenan production. This study investigated the effects of dietary E. cottonii polyphenol-rich extract (ECME) on breast cancer. In vitro assays showed that ECME was antiproliferative against oestrogen-dependent MCF-7 and oestrogen-independent MB-MDA-231 human breast-cancer cells (IC50 values of 20 and 42 μg/ml, respectively) but was non-toxic to normal cell lines. The ECME (150 and 300 mg/kg BW) was fed to female rats and, after 4 weeks, rat mammary tumour was induced using LA7 cells (inoculated subcutaneously). The ECME inhibited tumour development and erythrocyte lipid peroxidation in the cancer-induced rats, dose-dependently. It showed anti-oestrogenic effects on the rat estrous cycle and serum hormone levels. Electron microscopy and histopathology observations confirmed apoptosis in the rat mammary tumours. The polyphenol-rich ECME was tumour-suppressive via apoptosis induction, downregulating the endogenous oestrogen biosynthesis, and improving antioxidative status in the rats.

Apoptotic effects in oestrogen dependent and independent human breast cancer cells. The anti-estrogenic properties in female mammals.  Breast tumour prevention and suppression using sustainable cultivated seaweeds. Black Lion Research Letrone Black Lion Research is proud to announce the release of Letrone. This product is a natural anabolic aromatase inhibitor. Atractylodes Macrocephala- Atractylodes macrocephala Koidz (A. macrocephala), a Chinese medicinal herb, has been extensively used to treat digestive diseases in China and most other Asian countries (PPRC, 2005; Lee et al, 2007). Dry rhizomes of A. macrocephala are rich in sesquiterpenes and acetylenic compounds (Endo et al, 1979; Chen 1987; Huang et al, 1992; Lin et al, 1997). Typical polysaccharides atractan A, B, and C, present in A. macrocephala, have been reported to exhibit hypoglycaemic activities (Wang et al, 2000; Jia et al, 2003). Although atractylenolide I, atractylenolide II and atractylenolide III are all bioactive substances present in Atractylodes macrocephalae, the majority of research studies carried out in the recent years have focused on atractylenolide II and atractylenolide III (Kang et al., 2011b). Atractylenolide II is a marker substance present in Atractylodes macrocephalae which exhibits well-documented gastrointestinal inhibitory effects and anticancer activity (Zhang et al., 1999; Liu et al., 2005). Atractylenolide II is one of the main constituents present in the effective volatile oil fraction (Li et al., 2001), potentially effective in treating senile dementia. Atractylenolide III is a possible candidate for the treatment of human lung carcinoma (Kang et al., 2011a). Aromatase inhibition Primary targets for aromatase inhibition are atractylenolide 1 2 and 3 with atractylenolide 1 being exceptionally strong with 94.5% inhibition. Abstract:Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future. = http://www.jourlib.org/paper/162974#.VYtA8UYqPao Atractylenolides are exceptionally strong aromatase inhibitors that show exceptional oral bioavailability. There are many AIs in nature. During my research I must have found over 100 potentials but unfortunately 99.9999% of them are poorly absorbed orally which limits their potential. Atractylenolide in contrast is  very well absorbed. Sites- -“Atractylenolide I is absorbed quite well at all segments of intestine in rats and no specific absorption was founded in different segment.” -“Atractylenolide I can be classified into high penetrating drug. Passive diffusion dominates the absorptive transport behivior of atractylenolide I. Atractylenolide I can be absorbed in the whole intestinal segments and there is not a preferntial absorption zone in the intestine. The absorption and secretion of atractylenolide I are mediated by the efflux transport system, P-gp.” -“Abstract The intestinal permeability of three sesquiterpene lactones, atractylenolide I, II, and III, was investigated using the human Caco-2 cell monolayer model. The bidirectional permeability of the three compounds from the apical (AP) to the basolateral (BL) side and in the reserved direction was studied. The three compounds were assayed using HPLC. The P app values of atractylenolide I, II, and III were all at the level of 10 -5 cm / s, suggesting high intestinal permeability and good absorption. The bidirectional transport of the three compounds was time- and concentration-dependent, and indicated the main mechanism of the passive diffusion of the three compounds across the intestinal epithelium membrane. Moreover, atractylenolide I might be partly actively transported. “[/I] ANABOLIC- It was a huge loss when Formeron got canned because well….Ais are great but formestane was also anabolic. Letrone is a stout AI but it also shows significant anabolic potential by increasing endogenous hormones. In one animal study growth was increased by 20% compared to control when animals were fed polysaccharides of atractylodes macrocephala. The increase in growth was attributed to increases in- Growth hormone x30% IGF-1 x52% T3 x47% T4 x36% cAMP x21%

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Exotherm: Ethanol; Water; 5,7-Dehydroxyflavone; Atratcylodes Macrocephala; Cirsium oligophyllum; Stearoyl vanillylamide; Glycerine; Isopropyl mystrate; Propylene glycol; Triethylamine; Carbomer

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